gtrudГигиена труда и медицинская экологияOccupational Hygiene and Medical Ecology3106-5538Национальный центр гигиены труда и профессиональных заболеваний10.65491/1727-9712-2025-3-9-17gtrud-161Research ArticleПЕРЕДОВЫЕ СТАТЬИADVANCED CLAUSESМетоды оценки суммарного влияния множества факторов на проявление эффекта в медико-биологических исследованияхMethods for assessing the cumulative effect of multiple factors on the manifestation of the effect in biomedical researchhttps://orcid.org/0000-0002-9922-3604СабировЖ. Б.SabirovZ. B.

PhD, заведующий научной лаборатории профессиональной патологии

100017, г.Караганда, ул.Мустафина 15, e-mail: info@naoncgt.kz

PhD, Head of the Scientific Laboratory of Occupational Pathology 

100017, Karaganda, Mustafina str. 15, e-mail: info@naoncgt.kz

audacious_zap@mail.ruОтаровЕ.OtarovE. Z.

100017, г.Караганда, ул.Мустафина 15, e-mail: info@naoncgt.kz

100017, Karaganda, Mustafina str. 15, e-mail: info@naoncgt.kz

otarov_kgmu@mail.ruАлексеевА.AlekseevA. V.

100017, г.Караганда, ул.Мустафина 15, e-mail: info@naoncgt.kz

100017, Karaganda, Mustafina str. 15, e-mail: info@naoncgt.kz

lexaalexeev@mail.ruГребеневаО.GrebenevaO. V.

100017, г.Караганда, ул.Мустафина 15, e-mail: info@naoncgt.kz

100017, Karaganda, Mustafina str. 15, e-mail: info@naoncgt.kz

ol_grebeneva@bk.ruШадетоваА.ShadetovaA. Z.

100017, г.Караганда, ул.Мустафина 15, e-mail: info@naoncgt.kz

100017, Karaganda, Mustafina str. 15, e-mail: info@naoncgt.kz

alma7722@mail.ruНАО «Национальный центр гигиены труда и профессиональных заболеваний»КазахстанNC JSC «National Centre Occupational Health and Diseases»Kazakhstan20250810202503917Copyright © Сабиров Ж.Б., Отаров Е.Z., Алексеев А.V., Гребенева О.V., Шадетова А.Z., 20252025Сабиров Ж.Б., Отаров Е., Алексеев А., Гребенева О., Шадетова А.Sabirov Z.B., Otarov E.Z., Alekseev A.V., Grebeneva O.V., Shadetova A.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nauka.naoncgt.kz/jour/article/view/161

В медико-биологических исследованиях часто требуется количественно оценить совокупное воздействие множества факторов - как количественных, так и качественных - на определённый биомедицинский эффект. В данной статье рассматриваются подходы к нормализации данных, определению весов факторов, агрегированию информации и построению моделей для оценки суммарного влияния факторов. Обсуждаются как экспертные, так и основанные на данных методы, а также их применение в задачах прогнозирования состояния здоровья, оценки риска и принятия решений в биомедицине.

In biomedical research, it is often necessary to quantitatively assess the combined effect of multiple factors-both quantitative and qualitative-on a specific biomedical outcome. This article discusses approaches to data normalization, determination of factor weights, information aggregation, and model development for evaluating the cumulative influence of factors. Both expert-based and data-driven methods are examined, along with their application to health prediction, risk assessment, and decision-making in biomedicine.

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The authors declare that there are no conflicts of interest present.