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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gtrud</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена труда и медицинская экология</journal-title><trans-title-group xml:lang="en"><trans-title>Occupational Hygiene and Medical Ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">3106-5538</issn><publisher><publisher-name>Национальный центр гигиены труда и профессиональных заболеваний</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.65491/3106-5538-2026-3-62-73</article-id><article-id custom-type="elpub" pub-id-type="custom">gtrud-223</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФПАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OCCUPATIONAL PATHOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние вегетативного гомеостаза на состояние сердечно-сосудичой системы у жителей Приаралья</article-title><trans-title-group xml:lang="en"><trans-title>The effect of autonomic homeostasis on the cardiovascular system status of residents of the Aral sea region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баттакова</surname><given-names>Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Battakova</surname><given-names>Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шарбану Баттакова - д.м.н., профессор кафедры неврологии, психиатрии и реабилитологии.</p><p>100012, Караганда, Гоголя 40</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor of the Department of Neurology, Psychiatry and Rehabilitation, NСJSC «Karaganda Medical University».</p><p>100012, Karaganda, 40 Gogol Str.</p></bio><email xlink:type="simple">sharbanu_battakova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фазылова</surname><given-names>М-Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fazylova</surname><given-names>M-D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>100017, Караганда, ул. Мустафина 15</p></bio><bio xml:lang="en"><p>100017, Karaganda, Mustafina str. 15</p></bio><email xlink:type="simple">mangaz_dana@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожахметова</surname><given-names>К. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhakhmetova</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>100017, Караганда, ул. Мустафина 15</p></bio><bio xml:lang="en"><p>100017, Karaganda, Mustafina str. 15</p></bio><email xlink:type="simple">kunya-doc@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НАО «Медицинский университет Караганды»</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>NСJSC «Karaganda Medical University»</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НАО «Национальный центр гигиены труда и профессиональных заболеваний»</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>NCJSC «National Centre Occupational Health and Diseases»</institution><country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>18</day><month>10</month><year>2026</year></pub-date><volume>0</volume><issue>3</issue><fpage>62</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баттакова Ш., Фазылова М.А., Кожахметова К.М., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Баттакова Ш., Фазылова М.А., Кожахметова К.М.</copyright-holder><copyright-holder xml:lang="en">Battakova S., Fazylova M.A., Kozhakhmetova K.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nauka.naoncgt.kz/jour/article/view/223">https://nauka.naoncgt.kz/jour/article/view/223</self-uri><abstract><p>Изучено влияние вегетативного гомеостаза на сердечно-сосудистую систему жителей Приаралья. В исследовании приняли участие жители городов относящиеся к зоне «катастрофы», в зоне «кризисного состояния», в зоне «экологического предкризисного состояния», В контрольной группе были жители поселка Атасу не имеющие сердечно-сосудистых заболеваний (ССС). У лиц с донозологическим состоянием отмечалось увеличение напряжения центральных регуляторных функций со снижением функционального состояния систолического объема крови (СОК) и увеличением активности симпатической (AMo), парасимпатической отделов вегетативной нервной системы (Mo, HF), повышением индекса стресса (SI), что определяло преобладание активности центральных механизмов регуляции над автономными. По результатам исследования у лиц, имеющих ССС патологию имеется увеличение накопления никеля на 1 мг, а при накоплении диоксида серы снижение СОК, при увеличении меди – повышается ударный объем крови.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>The influence of autonomic homeostasis on the cardiovascular system of residents of the Aral Sea region was investigated. The study included residents of cities located in the “disaster zone,” the “crisis zone,” and the “pre-crisis ecological zone.” The control group consisted of residents of the settlement of Atasu without cardiovascular diseases (CVDs).</p><p>Individuals with prenosological conditions showed increased strain on central regulatory functions and a reduced functional measure of systolic blood volume (SV), accompanied by increased activity of the sympathetic (AMo) and parasympathetic (Mo, HF) divisions of the autonomic nervous system, as well as an elevated stress index (SI). These findings indicated the predominance of central regulatory mechanisms over autonomous mechanisms.</p><p>According to the study results, individuals with cardiovascular pathology showed a 1 mg increase in nickel accumulation. Sulfur dioxide accumulation was associated with a decrease in systolic blood volume, whereas increased copper levels were associated with an increase in stroke volume.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вегетативный гомеостаз</kwd><kwd>экология</kwd><kwd>дозовая нагрузка</kwd><kwd>сердечно-сосудистая система</kwd></kwd-group><kwd-group xml:lang="en"><kwd>autonomic homeostasis</kwd><kwd>ecology</kwd><kwd>dose load</kwd><kwd>cardiovascular system</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shadetova A. J., Mashina T. F., Alshynbekova G. K., Doroshilova A. V., Shokabaeva A. S., Sattybaev K. E. The Influence of Environmental Factors on the Adaptive Capacity of the Organism of the Inhabitants of the Aral Sea Region // International Journal of Applied and Fundamental Research. – 2016. – No. 2, Part 2. – P. 216–219.</mixed-citation><mixed-citation xml:lang="en">Shadetova A. J., Mashina T. F., Alshynbekova G. K., Doroshilova A. V., Shokabaeva A. S., Sattybaev K. E. The Influence of Environmental Factors on the Adaptive Capacity of the Organism of the Inhabitants of the Aral Sea Region // International Journal of Applied and Fundamental Research. – 2016. – No. 2, Part 2. – P. 216–219.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rzymski P., Marszelewski W., Rybak M., Klimaszyk P. et al. Health Impacts of the Aral Sea Disaster: Current State, Research Gaps, and Mitigation Perspectives in the North Aral Sea Region // Ambio. – 2026. – Vol. 55. – P. 2563–2577. – DOI: 10.1007/s13280-026-02385-z.</mixed-citation><mixed-citation xml:lang="en">Rzymski P., Marszelewski W., Rybak M., Klimaszyk P. et al. Health Impacts of the Aral Sea Disaster: Current State, Research Gaps, and Mitigation Perspectives in the North Aral Sea Region // Ambio. – 2026. – Vol. 55. – P. 2563–2577. – DOI: 10.1007/s13280-026-02385-z.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шавловская О. А. Терапия астенических расстройств // Медицинский совет. – 2013. – № 12. – С. 66–71.</mixed-citation><mixed-citation xml:lang="en">Shavlovskaya O. A. Terapiya astenicheskikh rasstroystv [Therapy of Asthenic Disorders] // Meditsinskiy sovet. – 2013. – No. 12. – P. 66–71.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sammito S., Thielmann B., Klussmann A. et al. Guideline for the Application of Heart Rate and Heart Rate Variability in Occupational Medicine and Occupational Health Science // Journal of Occupational Medicine and Toxicology. – 2024. – Vol. 19. – Art. 15. – DOI: 10.1186/s12995-024-00414-9.</mixed-citation><mixed-citation xml:lang="en">Sammito S., Thielmann B., Klussmann A. et al. Guideline for the Application of Heart Rate and Heart Rate Variability in Occupational Medicine and Occupational Health Science // Journal of Occupational Medicine and Toxicology. – 2024. – Vol. 19. – Art. 15. – DOI: 10.1186/s12995-024-00414-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jelmini J. D., Ross J., Whitehurst L. N., Heebner N. R. The Effect of Extended Shift Work on Autonomic Function in Occupational Settings: A Systematic Review and Meta-analysis // Journal of Occupational Health. – 2023. – Vol. 65, No. 1. – Art. e12409. – DOI: 10.1002/1348-9585.12409.</mixed-citation><mixed-citation xml:lang="en">Jelmini J. D., Ross J., Whitehurst L. N., Heebner N. R. The Effect of Extended Shift Work on Autonomic Function in Occupational Settings: A Systematic Review and Meta-analysis // Journal of Occupational Health. – 2023. – Vol. 65, No. 1. – Art. e12409. – DOI: 10.1002/1348-9585.12409.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Щукин И. А. Коррекция астенического синдрома // Медицинский алфавит. – 2013. – Т. 4, № 25. – С. 38–44.</mixed-citation><mixed-citation xml:lang="en">Shchukin I. A. Korrektsiya astenicheskogo sindroma // Meditsinskiy alfavit. – 2013. – Vol. 4, No. 25. – P. 38–44.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Баевский Р. М., Иванов Г. Г., Чирейкин Л. В. и др. Анализ вариабельности сердечного ритма при использовании различных электрокардиографических систем. – М. : ГРАМОТА, 2002. – 53 с.</mixed-citation><mixed-citation xml:lang="en">Baevskiy R. M., Ivanov G. G., Chireykin L. V. et al. Analiz variabel'nosti serdechnogo ritma pri ispol'zovanii razlichnykh elektrokardiograficheskikh sistem. – Moscow : GRAMOTA, 2002. – 53 p.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Heart Rate Variability Measurement to Assess Acute Work-Content-Related Stress of Workers in Industrial Manufacturing Environment – A Systematic Scoping Review // IEEE Transactions on Systems, Man, and Cybernetics: Systems. – 2023. – Vol. 53, No. 11. – P. 6685–6692. – DOI: 10.1109/TSMC.2023.3282141.</mixed-citation><mixed-citation xml:lang="en">Heart Rate Variability Measurement to Assess Acute Work-Content-Related Stress of Workers in Industrial Manufacturing Environment – A Systematic Scoping Review // IEEE Transactions on Systems, Man, and Cybernetics: Systems. – 2023. – Vol. 53, No. 11. – P. 6685–6692. – DOI: 10.1109/TSMC.2023.3282141.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ланг Т. А., Сесик М. Как описывать статистику в медицине: аннотированное руководство для авторов, редакторов и рецензентов / пер. с англ.; под ред. В. П. Леонова. – М. : Практическая медицина, 2016. – 480 с. – ISBN 978-5-98811325-6.</mixed-citation><mixed-citation xml:lang="en">Lang T. A., Sesik M. Kak opisyvat' statistiku v meditsine: annotirovannoe rukovodstvo dlya avtorov, redaktorov i retsenzentov [How to Report Statistics in Medicine: An Annotated Guide for Authors, Editors, and Reviewers] / transl. from English; ed. By V. P. Leonov. – Moscow : Prakticheskaya meditsina, 2016. – 480 p. – ISBN 978-598811-325-6.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Жанбеков Х. Н., Жетписбай Д. Ш., Сейтжанов А. Ф. Накопление и миграция тяжелых металлов в водном бассейне реки Сырдарьи // Вестник МОН НАН РК. – 2001. – № 3.</mixed-citation><mixed-citation xml:lang="en">Zhanbekov Kh. N., Zhetpisbay D. Sh., Seytzhanov A. F. Nakoplenie i migratsiya tyazhelykh metallov v vodnom basseyne reki Syrdar'i [Accumulation and Migration of Heavy Metals in the Syr Darya River Basin] // Vestnik MON NAN RK. – 2001. – No. 3.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
