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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gtrud</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена труда и медицинская экология</journal-title><trans-title-group xml:lang="en"><trans-title>Occupational Hygiene and Medical Ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">3106-5538</issn><publisher><publisher-name>Национальный центр гигиены труда и профессиональных заболеваний</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">gtrud-98</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНСКАЯ ЭКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL ECOLOGY</subject></subj-group></article-categories><title-group><article-title>Оценка цитогенетического состояния у населения, проживающих в зоне экологической предкризиса</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the cytogenetic status of the population living in the Area before the environmental crisis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сабиров</surname><given-names>Ж. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sabirov</surname><given-names>Zh. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Karaganda</p></bio><bio xml:lang="en"><p>Karaganda</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">RSGE “National center of Labour hygiene and Occupational diseases” of Ministry Healthcare and Social Development of the Republic of Kazakhstan<country>Казахстан</country></aff><aff xml:lang="en">RSGE “National center of Labour hygiene and Occupational diseases” of Ministry Healthcare and Social Development of the Republic of Kazakhstan<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>70</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сабиров Ж.Б., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сабиров Ж.Б.</copyright-holder><copyright-holder xml:lang="en">Sabirov Z.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nauka.naoncgt.kz/jour/article/view/98">https://nauka.naoncgt.kz/jour/article/view/98</self-uri><abstract><p>По данным Всемирной организации здравоохранения (ВОЗ) каждое четвертое заболевание в мире имеет прямую связь с воздействием загрязнения окружающей среды, в патогенезе практически каждого заболевания имеет место отрицательное влияние экологических факторов. В Казахстане продолжает оставаться сложной экологическая ситуация в Приаралье, законодательно признанной зоной экологического бедствия. Проблема умирающего Аральского моря обусловила экологическую катастрофу природы огромного региона Центральной Азии. Такая экологическая ситуации оказывает негативное влияние на здоровье населения, в том числе и генотоксическое и может проявляться как хромосомные аберрации (ХА).</p></abstract><trans-abstract xml:lang="en"><p>According to the world health organization (WHO) every fourth disease in the world has a direct link with the impact of environmental pollution in the pathogenesis of virtually every disease has a negative influence of ecological factors. In Kazakhstan remains a difficult environmental situation in the Aral sea, the legally recognized zone of ecological disaster. The problem of the dying Aral sea has caused an environmental catastrophe of nature the vast region of Central Asia. This environmental situation has a negative impact on public health, including genotoxic and can manifest as chromosomal aberration (CA).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ДНК</kwd><kwd>хромосомные аберрации</kwd><kwd>тяжелые металлы</kwd><kwd>генотоксические</kwd><kwd>структурные аномалии</kwd><kwd>Приаралье</kwd></kwd-group><kwd-group xml:lang="en"><kwd>DNA</kwd><kwd>chromosomal aberrations</kwd><kwd>heavy metals</kwd><kwd>genotoxic</kwd><kwd>structural anomalies</kwd><kwd>the Aral sea area</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The law of the Republic of Kazakhstan dated 30 June 1992 "On social protection of citizens affected by the consequences of the ecological disaster in the Aral sea". – 1992.</mixed-citation><mixed-citation xml:lang="en">The law of the Republic of Kazakhstan dated 30 June 1992 "On social protection of citizens affected by the consequences of the ecological disaster in the Aral sea". – 1992.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rakhmanin Yu.A., Zhurkov V.S., Revazova Y.A., Sycheva L.P. 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