Assessment of the impact of physical and chemical factors (at the level of 1.5 MAC, MPC) on accelerated aging of model organisms (based on the results of a chronic experiment)

In a 180-day experiment on 120 Wistar rats, the effects of isolated exposure to vibration, noise (81.5–85.3 dBA), and a 4-component mixture of hydrocarbons (1.5 MAC) were studied. It was found that prolonged exposure to these factors at a level of 1.5 MAC/POC leads to accelerated aging, manifested by a significant shortening of telomeres, polymorphic pathological changes in two or more internal organs, reduced behavioral activity, and external signs of senility. The results confirm the role of occupational factors as inducers of premature aging and justify the need to strengthen preventive measures for workers operating under such conditions.

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