In biomedical research, it is often necessary to quantitatively assess the combined effect of multiple factors-both quantitative and qualitative-on a specific biomedical outcome. This article discusses approaches to data normalization, determination of factor weights, information aggregation, and model development for evaluating the cumulative influence of factors. Both expert-based and data-driven methods are examined, along with their application to health prediction, risk assessment, and decision-making in biomedicine.

With the growing demand for digital healthcare, especially following the COVID-19 pandemic, understanding how medical professionals interact with e-health technologies and how this technological interaction will impact clinical practice is becoming increasingly relevant. The COVID-19 pandemic served as a catalyst and accelerated the development of the digital healthcare space to ensure the delivery of medical services under the prevailing conditions.

Migration has a significant impact on the spread of HIV. According to the UNAIDS Report “Global AIDS Update 2022”, there is an increase in the number of new HIV cases in Eastern Europe and Central Asia. Key factors contributing to the spread of HIV among migrants include low levels of medical and legal literacy, discrimination, lack of social support, and difficulties in accessing antiretroviral therapy. Harmonizing legislation between countries regarding HIV-positive migrants is seen as one of the ways to address this issue.

Harmful occupational factors in the mining industry are independent risk factors for the development of pulmonary pathology. It was found that drillers (tunnelers) are most frequently affected, with an average age of 41.6±1.2 years and work experience of up to 10 years. As the severity of silicosis increases, the level of systemic inflammatory factors (SIF) also rises. The presence of second- and third-stage silicosis and elevated SIF levels made it possible to reliably predict the likelihood of developing occupationnally induced pulmonary pathology.

The results of neurophysiological studies of the intersegmental connection of spinalcord motor neuronsin the regulation of neuromuscular transmission in coal miner sunder the influence of a complex of industrial factorsare presented. Some mechanisms of neuromuscular transmission disorders in miners with chronic lumbosacral radiculopathy have been revealed.

The dysfunction of the autonomic vascular system with damage to the neuromascular apparatus, characterized by electrophysiological polymorphism, the degree of damage to nervetrunks in miners with com bined pathology, was revealed.

The article explores the role of the nasopharyngeal microbiota in the development of ENT diseases. It describes the composition of the normal microbiota and its influence on the immune response of the body. The consequences of dysbiosis are examined, including an increased risk of infections such as sinusitis, otitis, and tonsillitis. The impact of antibiotics on the microbiota is discussed, as well as potential strategies for restoring its balance using probiotics. The importance of studying the nasopharyngeal microbiota for the prevention and treatment of ENT diseases is emphasized, along with the need for further research in this area.