The analysis of oxidative manifestations of hepatotoxicity of persistent organic pollutants and the ways of its overcoming. Special attention is paid to oxymethyluracil (5-hydro-6-methyluracil). The generalized results of studies hepatoprotective effects and antioxidant properties of pyrimidines and complex compounds, the pyrimidines with succinate, ascorbate, fumarate, glutathione and acetyl in a model of toxic liver injury. The substantiation of further research original new antioxidants on the basis of pyrimidines as a means of protection against the hepatotoxicity of persistent organic pollutants – chlorinated hydrocarbons and polychlorinated biphenyls.

The article presents that in the period of professional activity exacerbating and normalizing effect of endogenous risk factors should be assessed with one of the leading exogenous factors of professional risk. Physiological functions of the body belong to an easily measured, sensitive and reversible biomarkers and therefore successfully used in the development of the problem of IPR. The calculation of individual safe work experience, based on the evaluation of IPR could serve as an effective measure for the preservation of health for each employee, which corresponds to the global strategy.

In article results of researches and an ecological assessment of noise level of a transport stream in the territory of the item of Aksukent of the Southern Kazakhstan area are yielded. The analysis of the data obtained as a result of researches is carried out.

The article presents data on the subjective assessment of the state of water supply Irgiz township. Drinking water - a necessary element of life-support, on its quality depends on the state of human health, the level of sanitary and epidemiological welfare, social stability of society.

The article gives a comparative analysis of the feeding habits of the population of the Aral sea region living in 3 areas: disaster, crisis and pre. One of the integral indicators of ecological troubles is an eating disorder in any form.

The article presents the comparative aspects of incidence of nervous system are given in zones of ecological trouble. The ten settlements of the Aral region and geographical location of the zones of the disaster (Aral c., Aiteke bi v., and Shalkar c.), crisis (Shiely v., Zhalagash v., Zhosaly v.), pre-condition (the item Irgiz, Arys, the item of Ulytau) and comparison (the item of Atasu) of Kazakhstan are analyzed. The incidence assessment among the surveyed population is given, the leading pathology in these regions is allocated.

The territory of Aris belongs to the continental climate type, though similar to the sharply continental. Winter is short, moderately warm, there are a thaw to +8.4°C and frozen to -13.3°C, with high humidity up to 89%. Summers are hot, long with a maximum ambient temperature of up to +38°C, which manifests itself dry air (25-45%), a slight amount of precipitation (42-161 mm).

The article analyzes the structure and the prevalence of disease among the adolescent population in environmentally disadvantaged areas of Kyzylorda region. Research conducted in the town of Aralsk, Aiteke village, Zhalagash village, Zhosaly village, Shieli village, located in the Aral Sea area.Leading pathology was introduced supposedly eco-dependent diseases of different classes.Five leading classes are part of a group of suspected environmental diseases, that may be indicators of evidence of direct and indirect influence of adverse environmental factors on the incidence region of the adult population.Retrospective analyzed parameters was 10 years, from 2004 - 2013.

Weather-climatic conditions continue to remain the most important factors among the environment, largely determines the living conditions of the person throughout of his life. Increasing demands on quality and quantity of the natural environment determine the relevance of the climatic research unit indicators of the study area, because climatological place of residence, defines the aspects of its life.

The results of comprehensive research on the assessment of meteorological factors in Turkestan revealed a sharp temperature fluctuation during the day up to 130С, high humidity performance up to 96% and wind speed of 6 m/s.

The article presents retrospective analysis and assessment of the guality drinking water, water open reservoirs Ridder city. Index of pollution of drinking water was 0.21 a.u., which means clear water (water guality class 2). Index of water pollution of open reservoirs was 1.4 a.u., which means moderately polluted water (water guality class 3).

The work describes preclinical evaluation of the influence of unfavourable environmental factors on the functional health status of the population living in the city of Arys. The results indicate poor adaptation group with premorbid health status, which is the result of a surge of the functional system.